A/G Ratio

Total Protein Levels

  • Low = liver disorder, kidney disorder, malabsorption of kidney; malnutrition
  • High = chronic inflammation, infections (viral hepatitis or HIV), bone marrow diseases, multiple myeloma

A/G Ratio (normally, there is a little more albumin than globulins, so slightly >1)

  • Low = decreased albumin (cirrhosis, nephrotis syndrome) or increased globulins (MM, autoimmune diseases)
  • High = increased albumin <?> or decreased globulin (leukemias, genetic deficiencies)

Next tests: liver enzyme tests, SPEP

NOTE:  plasma expansion decreases total protein but A/G ratio will be normal because both albumin and globulin will be diluted to the same extent