Gabapentin

Dose:  
start with 300mg OD, then 300 BID, then 300 TID; titrate up to max 3,600 mg/day
*Doses >1,800 mg usually no greater benefit

Mechanism of Action:
Gabapentin is structurally related to GABA, but does not bind to GABA A or GABA B receptors; does not influence synthesis or uptake of GABA
binds to Gabapentin sites throughout brain (with volatage-gated calcium channels that has the alpha-2-delta-1 subunit – A2D1), located presynaptically, and modulates release of excitatory neurotransmitters that are involved in seizures or pain perception

Dose in renal failure:

Table 5

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