Glycoprotein IIb/IIIa and Its Inhibitors

Glycoprotein IIb/IIIa

  • AKA integrin αIIbβ3
  • integrin complex found on platelets
  • a receptor for fibrinogen and vWF
  • aids platelet activation

Drugs Targeting Glycoprotein IIb/IIIa

  1. abciximab
  2. eptifibatide
  3. tirofiban

gp2b3a table

Mechanism of action

ADP, etc. activates platelet which leads to conformational change in platelet gpIIb/IIIa receptors (activated member receptor complex) that induces binding to fibrinogen (Factor I), resulting in platelets sticking together – a clot; coagulation cascade stabilizes the clot as thrombin (Factor IIa) converts soluble fibrinogen into insoluble fibrin strands which are cross-linked by Factor XIII to form a stable blood clot


Pathology related to Glycoprotein IIb/IIIa:

  • GLanzmann’s thrombasthenia – defects in glycoprotein IIb/IIIa
  • ITP – autoantibodies against glycoprotein IIb/IIIa

References,. ‘Cardiovascular Drugs’. N.p., 2015. Web. 19 Oct. 2015.

Wikipedia,. ‘Glycoprotein Iib/Iiia’. N.p., 2015. Web. 14 Oct. 2015.,. N.p., 2015. Web. 19 Oct. 2015.

3 thoughts on “Glycoprotein IIb/IIIa and Its Inhibitors

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s