Glycoprotein IIb/IIIa and Its Inhibitors

Glycoprotein IIb/IIIa

  • AKA integrin αIIbβ3
  • integrin complex found on platelets
  • a receptor for fibrinogen and vWF
  • aids platelet activation

Drugs Targeting Glycoprotein IIb/IIIa

  1. abciximab
  2. eptifibatide
  3. tirofiban

gp2b3a table

Mechanism of action

ADP, etc. activates platelet which leads to conformational change in platelet gpIIb/IIIa receptors (activated member receptor complex) that induces binding to fibrinogen (Factor I), resulting in platelets sticking together – a clot; coagulation cascade stabilizes the clot as thrombin (Factor IIa) converts soluble fibrinogen into insoluble fibrin strands which are cross-linked by Factor XIII to form a stable blood clot

gp2b3a

Pathology related to Glycoprotein IIb/IIIa:

  • GLanzmann’s thrombasthenia – defects in glycoprotein IIb/IIIa
  • ITP – autoantibodies against glycoprotein IIb/IIIa

References

Slideshare.net,. ‘Cardiovascular Drugs’. N.p., 2015. Web. 19 Oct. 2015.

Wikipedia,. ‘Glycoprotein Iib/Iiia’. N.p., 2015. Web. 14 Oct. 2015.

Img.medscape.com,. N.p., 2015. Web. 19 Oct. 2015.

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One thought on “Glycoprotein IIb/IIIa and Its Inhibitors

  1. ig February 19, 2016 at 7:48 am Reply

    This web site truly has all of the information I wanted about this subject and didn’t know who to ask.

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