- AKA integrin αIIbβ3
- integrin complex found on platelets
- a receptor for fibrinogen and vWF
- aids platelet activation
Drugs Targeting Glycoprotein IIb/IIIa
Mechanism of action
ADP, etc. activates platelet which leads to conformational change in platelet gpIIb/IIIa receptors (activated member receptor complex) that induces binding to fibrinogen (Factor I), resulting in platelets sticking together – a clot; coagulation cascade stabilizes the clot as thrombin (Factor IIa) converts soluble fibrinogen into insoluble fibrin strands which are cross-linked by Factor XIII to form a stable blood clot
Pathology related to Glycoprotein IIb/IIIa:
- GLanzmann’s thrombasthenia – defects in glycoprotein IIb/IIIa
- ITP – autoantibodies against glycoprotein IIb/IIIa
Slideshare.net,. ‘Cardiovascular Drugs’. N.p., 2015. Web. 19 Oct. 2015.
Wikipedia,. ‘Glycoprotein Iib/Iiia’. N.p., 2015. Web. 14 Oct. 2015.
Img.medscape.com,. N.p., 2015. Web. 19 Oct. 2015.