Anti-factor Xa Levels (Enoxaparin)

Standard dosing (enoxaparin 30q12h) may be inadequate in high risk trauma; lead to inc rates of DVT

Monitor antifactor Xa level

  • Normal value = <0.1
  • >0.5 considered therapeutically anticoagulated
  • 0.2 to 0.5 considered target level for prophylaxis

–Send trough before 4th dose

  • If normal –>increase to 40mg q12h; then 50 sq q12h or even 60 q12h

–With this approach, majority of patients require enoxaparin in 40 q12h dose

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