Small but handy table:  Serotonin-norepinephrine reuptake inhibitors (SNRIs) vs. Selective Serotonin reuptake inhibitors (SSRIs)


SNRIs are a class of drugs used for the treatment of depression in patients in whom SSRIs are ineffective. 5- HT (serotonin) and norepinephrine (noradrenaline) are released from the nerve terminal to the synaptic cleft and bind to post-synaptic receptors. Drugs like venlafaxine, duloxetine, and the newer desvenlafaxine – all of them Serotonin-Norepinephrine Reuptake Inhibitors- block proteins in the pre-synaptic neuron that act as re-uptakers. This increases the concentration of both neurotransmitters at the synaptic cleft.





“Differences Between Tricyclic Antidepressants And Snris Mechanism Of Action | CME At Pharmacology Corner”. N.p., 2016. Web. 8 May 2016.

Finkel, Richard, Michelle Alexia Clark, and Luigi X Cubeddu. Pharmacology. Philadelphia: Lippincott Williams & Wilkins, 2009. Print.


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