Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH)
Research Question: Will platelet transfusion compared to standard of care reduce death or dependence in patients who present with ICH who took antiplatelet drugs within 7 days?
- multicenter, open-label, randomized trial
- 60 hospitals in Netherlands, UK and france
- Inclusion: supratentorial ICH, antiplatelets for 7 days, GCS at least 8
- standard of care vs standard of care + platelet transfusion within 90 minutes of CT scan
- primary outcome: shift towards death or dependence on mRS at 3 months
- 190 participants (97 treatment, 93% standard of care)
- death or dependence at 3 months: adjusted OR 2.05 95% CI 1.18-3.56; p=0.0114
- serious adverse event: 42% vs 29%
- deaths during hospital stay: 29% vs 24%
Baharoglu, M Irem et al. “Platelet Transfusion Versus Standard Care After Acute Stroke Due To Spontaneous Cerebral Haemorrhage Associated With Antiplatelet Therapy (PATCH): A Randomised, Open-Label, Phase 3 Trial”. The Lancet 387.10038 (2016): 2605-2613.