Equations for Phenytoin Dosing and Monitoring

#1.  loading dose for subtherapeutic phenytoin concentration:

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#2. adjust for renal disease

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#3. adjust for hypoalbuminemia

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#4. adjust in elderly and critically ill with hypoalbuminemia

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**Vd = volume of distribution (0.5-1 L/kg)

 

Reference:

Tesoro, E. P. and G. M. Brophy. “Pharmacological Management Of Seizures And Status Epilepticus In Critically Ill Patients”. Journal of Pharmacy Practice 23.5 (2010): 441-454.

**Thanks to Benjamin Wee (Clinical Pharmacist @ Lenox Hill Hospital) for giving me this resource.
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