#1. loading dose for subtherapeutic phenytoin concentration:
#2. adjust for renal disease
#3. adjust for hypoalbuminemia
#4. adjust in elderly and critically ill with hypoalbuminemia
**Vd = volume of distribution (0.5-1 L/kg)
Tesoro, E. P. and G. M. Brophy. “Pharmacological Management Of Seizures And Status Epilepticus In Critically Ill Patients”. Journal of Pharmacy Practice 23.5 (2010): 441-454.
**Thanks to Benjamin Wee (Clinical Pharmacist @ Lenox Hill Hospital) for giving me this resource.