AUC CSF / AUC Serum of IV antibiotics

This information may not be useful to most readers, but is part of my ongoing project to collect data on the serum vs CSF concentrations from intravenous administration of antibiotics.  This data is useful when deciding whether intrathecal drug administration will improve drug delivery to the CNS.

 

AUCCSF/AUCS

uninflamed
ceftriaxone 0.007
dicloxacillin 0.0087
piperacillin 0.034
ceftazidime 0.057
tazobactam 0.106
cefotaxime 0.12
sulfamethoxazole 0.12
fosfomycin 0.18
trimethoprim 0.18
valacyclovir 0.19
doxycycline 0.2
rifampicin 0.22
netilmicin 0.24
praziquantel 0.24
lopinavir 0.29
acyclovir 0.31
abacavir 0.35
moxifloxacin 0.46
ofloxacin 0.62
levofloxacin 0.71
zidovudine 0.75
meropenem 0.047, 0.21, 0.25
indinavir 0.06-0.15
vancomycin 0.18, 0.14
ciprofloxacin 0.24, 0.43
foscarnet 0.27, 0.43
sulfadiazine 0.27-0.33
albendazole 0.38, 0.43
chloramphenicol 0.6-0.7
linezolid 0.9 (0.8-1)

 

 

inflamed
amoxicillin 0.058
imipenem 0.14
clarithromycin 0.18
doxycycline 0.2
piperacillin 0.32
meropenem 0.39
voriconazole 0.46
flucytosine 0.74
metronidazole 0.87
ciprofloxacin 0.92
cefotaxime 0.04, 0.17
cefpirome 0.145, 0.31
foscarnet 0.23, 0.66
sulfamethoxazole 0.24-0.30
vancomycin 0.30 (0.29-0.48)
trimethoprim 0.42-0.51
chloramphenicol 0.6-0.7
fluconazole 0.86 (0.74-0.89)
isoniazid 0.86 (0.78-1.17)

 

<click here for MS excel database file> 

 

Reference:

Nau, R., F. Sorgel, and H. Eiffert. “Penetration Of Drugs Through The Blood-Cerebrospinal Fluid/Blood-Brain Barrier For Treatment Of Central Nervous System Infections”. Clinical Microbiology Reviews 23.4 (2010): 858-883.

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