Production of arginine vasopressin – by magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus. Transported to the neurohypophysis via hypothalamo-hypophyseal tract. Injury to these structures leads to DI.
Triphasic response in DI:
- First phase – DI caused by “stunning” of the magnocellular neurons, no AVP secretion.
- Second phase – injured hypothalamic cells degenerate and release their stored AVP
- Third phase – if majority of these neurons are destroyed, permanent phase of DI begins
Schreckinger, Matthew, Nicholas Szerlip, and Sandeep Mittal. “Diabetes Insipidus Following Resection Of Pituitary Tumors”. Clinical Neurology and Neurosurgery 115.2 (2013): 121-126.