Proposed Mechanism for HCP causing Takotsubo:
Sympathetic control of the heart is mediated by hypothalamic nuclei that abut the walls of the third ventricle. Specifically, dysfunction of PVN and DMN has been linked to catecholamine-induced myocardial necrosis. Hydrocephalus may disrupt these centers, although intracranial hypertension may not be necessary for this to occur.
*Paraventricular nucleus (PVN): TRH release, CRH relesase, oxytocin release, vasopressin release, somatostatin release
**Dorsomedial nucleus (DMN): BP, HR, GI stimulation
Gharaibeh, Kamel, Jackie Scott, and Nicholas A. Morris. “Neurogenic Stress Cardiomyopathy Precipitated By Acute Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage.” Neurocritical Care (2017): n. pag. Web. 14 Aug. 2017.
“Hypothalamus.” En.wikipedia.org. N.p., 2017. Web. 14 Aug. 2017.