Monthly Archives: May 2018

Status Epilepticus Meds Calculator

I created this spreadsheet that automatically calculates AED drug doses in status epilepticus.  Download the file and save in your desktop for easy access, or pull up the Google spreadsheet which I have made publicly accessible.

The only information to input is the patient’s weight in Kg (see cell in RED).  The spreadsheet has two columns, one with more details and a second column that is simpler (and using more conservative values).  Please verify all dosages with the clinical pharmacist before starting any AED medication.

All dosages are from UpToDate.  If multiple dosages are listed, I picked whatever Neurocritical Care Society recommends.

 

Link to webpage:  Public Google Spreadsheet: Status Ep Meds Calculator

Link to file: Status Epilepticus Medications

  • Cells in red = user can input data.
  • Cells in gray = data calculated by spreadsheet.

 

REFERENCE:

UpToDate.  Drug Information on Propofol, Midazolam, Ativan, Levetiracetam, Lacosamide and Valproic Acid.  Accessed 05/10/2018.

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Deferoxamine in ICH

Deferoxamine: iron chelator that decreases ability of free iron in brain tissue to cause oxidative injury

Phase I Study of deferoxamine mesylate (DFO) in patients with ICH demonstrated tolerability of doses up to 62mg/kg/day to max of 6000 mg/d x 5 days without major safety concerns.

Pilot trial of same dosage x 3 days shows lower perihematomal edema in patients treated with deferoxamine.

Phase 2 trial at this dose stopped due to increased occurrence of ARDS.

Recruitment for lower-dose phase 2 iDEF trial ongoing.

REFERENCE:

Burns, J., Fisher, J. and Cervantes-Arslanian, A. (2018). Recent Advances in the Acute Management of Intracerebral Hemorrhage. Neurosurgery Clinics of North America, 29(2), pp.263-272.