For patients with COVID-19, we are using drugs that prolong QT-interval. The risk of life-threatening arrhythmias from QT prolongation may be higher. This article reports a scoring system to identify patients that are at risk for QT prolongation.
The study found that the following factors predicted QTc prolongation: female, sepsi, LV dysfunction, administration of QT-prolong drug, >= 2 QT prolonging drugs, loop-diuretic, age >68, serum K <3.5, admitting ATc >450ms.
A risk score was developed. Risk was classified as low (score of 0-6), moderate (7-10) and high (11-21).
A high risk score >11 was associated with 74% Sn and 77% Sp (PPV 79% NPV 76) for predicting QTc prolongation. Incidence of QTc prolongation 15% in low risk, 37% in moderate risk and 73% in high risk.
Tisdale, J., Jaynes, H., Kingery, J., Mourad, N., Trujillo, T., Overholser, B., & Kovacs, R. (2013). Development and Validation of a Risk Score to Predict QT Interval Prolongation in Hospitalized Patients. Circulation: Cardiovascular Quality And Outcomes, 6(4), 479-487. doi: 10.1161/circoutcomes.113.000152